[7] Ethiopian runner Tigst Assefa set a new marathon world record for women, winning the race with a time of 2:11:53, beating the previous world record of 2:14:04, set by Kenyan runner Brigid Kosgei at the 2019 Chicago Marathon by over two minutes.

[12][13][14][15] Kenyan runner Eliud Kipchoge achieved a record fifth Berlin Marathon victory, winning the men's race with a time of 2:02:42.

[12][16][15] Swiss wheelchair athletes Marcel Hug and Catherine Debrunner won their races with finish times of 1:23:07 and 1:34:16, respectively.

[20] Kipchoge was the holder of the marathon world record, which he had set with a finish time of 2:01:09 at this race the previous year.

[23] Kipchoge stated that his main goal is to win three consecutive Olympic gold medals, and that he believed running in Berlin was the best way to prepare for this.