Incumbent Governor John Bel Edwards was term-limited and could not seek re-election to a third consecutive term in office.

This was the first time a candidate won a Louisiana gubernatorial election without a runoff since fellow Republican Bobby Jindal was re-elected in 2011.

John Bel Edwards, a moderate Democrat, was able to win two terms as governor and overcome the state's partisan lean by diverging from the national party on certain policy matters, such as abortion, while also appealing to Louisiana's contemporary Democratic voting base.

[6] The Louisiana Republican Party endorsed Attorney General Jeff Landry's campaign on November 7, 2022, a year before the election.

Michael DiResto, a member of the Republican State Central Committee, believed "the idea that a small cabal would preempt the democratic process literally under the cover of darkness and in a smoke-filled Zoom goes against the foundational values of our party.