Aryna Sabalenka defeated Iga Świątek in the final, 6–3, 3–6, 6–3 to win the women's singles tennis title at the 2023 Madrid Open.

It was also the first time since 2000 that the top two players on the WTA Tour contested back-to-back finals, after Świątek won in Stuttgart the week prior (the last time this occurred was when Lindsay Davenport and Martina Hingis contested the 2000 Indian Wells and Miami finals).

[citation needed] Ons Jabeur was the reigning champion,[2] but withdrew due to a left calf injury.

‡ The player was not required to count points for the 2022 tournament due to a long-term injury exception.

§ The player did not qualify for the main draw in 2022 but is defending points from a WTA 125 tournament (Saint-Malo).