LSU's victory gave them their first women's basketball national championship and the fourth in the head coaching career of Kim Mulkey.

Much media attention was directed to Angel Reese for a taunting gesture made to Iowa's Caitlin Clark near the end of the game.

It was also the most-viewed college sporting event ever shown on the ESPN+ streaming service, and the year-over-year viewership from the 2022 championship game more than doubled.

As a top-four seed, LSU hosted first- and second-round games at their home arena, Pete Maravich Assembly Center.

2 seed in the Big Ten tournament, where they defeated Purdue,[23] Maryland,[24] and Ohio State on consecutive days to win the conference championship.

7 seed Florida State,[27] and Iowa defeated Georgia by eight points in the second round to advance to the regional semifinal.

5 seed Louisville in a game whose viewership bested any NBA on ESPN broadcast during the 2022–23 season[30] to reach the Final Four of the NCAA tournament for the first time since 1993.

[35] LSU won the opening tip, but Iowa scored the game's first point with a two-point field goal from Monika Czinano.

LSU's Flau'jae Johnson gave the Tigers their first lead seconds later with a three-point field goal, though Iowa took it back with shots made by Kate Martin and Caitlin Clark.

The teams traded baskets and tied at 9–9 and 12–12 before a three-pointer by Kateri Poole and a free throw by Angel Reese put LSU in front by four points.

Free throws and layups allowed Iowa to make up some of the deficit, but back-to-back three-point shots by Carson pushed LSU's lead to as many as thirteen points with four minutes until halftime.

After a layup by Marshall, the score remained 49–38 for nearly a minute until Iowa's McKenna Warnock made a free throw.

Marshall attempted a three-pointer for the Hawkeyes with 15 seconds left, but she missed and a rebound by Williams allowed LSU to run out the clock and secure the 17-point victory for their first national championship in program history.

[37][38] Reese was named the Most Outstanding Player (MOP) of the Final Four; she finished the championship game with a double-double, scoring 15 points and securing 10 rebounds, and tallied a season-high five assists.

[39] She was named to the all-tournament team alongside teammates Morris and Carson, Iowa's Clark, and Zia Cooke of South Carolina.

[39] The next night, Reese's cousin Jordan Hawkins helped the University of Connecticut win its fifth men's title in school history.

[41] 0 The championship game was televised in the United States by ABC, with Ryan Ruocco on play-by-play commentary, Rebecca Lobo as the analyst, and Holly Rowe and Andraya Carter as sideline reporters.

[43] This marked an increase in viewership of 103% from the championship game the year prior (which was televised exclusively by ESPN in primetime), and was also the most-viewed college sporting event ever shown on the ESPN+ streaming service.

[45] In the immediate aftermath of the game, much attention was directed to a gesture made by Angel Reese towards Caitlin Clark.

[49] She remarked that she wanted Iowa to be invited to the White House along with LSU, as an addition to the custom of the president and first lady hosting the national champions.

[52] This comment drew ire from several people, including Reese, Alexis Morris, ESPN host Stephen A. Smith, and Representative Troy Carter, and the matter was clarified the following day by Biden's press secretary, Vanessa Valdivia, who said that LSU would be the only team invited to the White House celebration.