They were led by head coach Darin Hendrickson, in his 16th season with the program.

They reached the finals of the 2023 Atlantic 10 Conference baseball tournament where they lost to George Mason.

The 2022 Saint Louis Billikens baseball team notched a 29–24 (14–9) regular season record earning the third seed and in the 2022 Atlantic 10 Conference baseball tournament.

Infielder Cam Redding was named to the All-Atlantic 10 Preseason team.

Saint Louis was picked to finish fourth the Atlantic 10.