The 2022 UNAF U-20 Tournament, which also served as the qualifiers for the Africa U-20 Cup of Nations, took place between 18 and 24 October 2022 in Suez, Egypt.

The WAFU-UFOA Zone A qualifiers for the Africa U-20 Cup of Nations were hosted by Mauritania with the matches played between 28 August–11 September 2022.

The WAFU-UFOA Zone B qualifiers for the Africa U-20 Cup of Nations were hosted by Niger with the matches played between 7–20 May 2022.

The UNIFFAC qualifiers for the Africa U-20 Cup of Nations were held in Congo between 8–14 December 2022.

However, on 25 November, São Tomé and Príncipe withdrew from the competition, with Chad and Equatorial Guinea following suit.

[note 1] The four remaining teams were then placed in one group with the winners and the runners-up qualifying for the final tournament.

The CECAFA qualifiers for the Africa U-20 Cup of Nations were hosted by Sudan between 28 October and 11 November 2022.

The COSAFA qualifiers for the Africa U-20 Cup of Nations were hosted by Eswatini between 7–16 October 2022.