Led by 5th-year head coach Alvin Parker, the Panthers compiled an overall record of 10–2 with a mark of 7–1 in conference play; winning the CIAA championship.
Four Virginia Union Panthers players left via the NCAA transfer portal during or after the 2022 season.
[50] at Tom Benson Hall of Fame Stadium • Canton, Ohio On January 13, 2023, Virginia Union was picked to play against fellow HBCU Morehouse in the fourth-annual Black College Football Hall of Fame Classic.
[51] Virginia Union came into the game looking to build upon the previous seasons success as they finished with a 9–2 record and made an appearance in the NCAA Division II playoffs under head coach Alvin Parker.
[52] Virginia Union beat Morehouse while running back Jada Byers scored three touchdowns and the Panther defense held the Maroon Tigers to less than 250 total-yards of offense throughout the entire game.