The 2024–25 AFC Champions League Two knockout stage will be played from 11 February to 17 May 2025.
In the knockout stage, the 16 teams will play a single-elimination tournament.
Extra time and penalty shoot-out will be used to decide the winners if necessary (Regulations Article 10).
The order of matches (home vs away) will be determined at the draw, except for the final.
The final venue was pre-determined on a rotation basis, with the match hosted by the team from the East Region.