The 2024–25 Charlotte 49ers women's basketball team represents the University of North Carolina at Charlotte during the 2024–25 NCAA Division I women's basketball season.

The 49ers, led by first-year head coach Tomekia Reed, play their home games at Dale F. Halton Arena in Charlotte, North Carolina, as second-year members of the American Athletic Conference.

[1] They were upset by Tulane in the second round of the AAC tournament.

[2] On April 17, 2024, it was announced that head coach Cara Consuegra would be stepping down from her position, in order to take the head coaching position at Marquette.

[3] On April 25, the school announced that they would be hiring Jackson State head coach Tomekia Reed as the team's new head coach.