The 2024–25 EHF European League main round was played between 11 February and 4 March 2025 to determine the twelve teams advancing to the knockout stage of the 2024–25 EHF European League.
[1] In each group, teams played against the teams they didn't play in the group stage.
Games involving teams who advanced from the same group in the previous round are carried over to the main round.
In the group stage, teams were ranked according to points (2 points for a win, 1 point for a draw, 0 points for a loss), and if tied on points, the following tiebreaking criteria were applied, in the order given, to determine the rankings: All times are local.