The 2024–25 Iowa State Cyclones women's basketball team represents Iowa State University during the 2024–25 NCAA Division I women's basketball season.

The Cyclones, led by thirtieth-year head coach Bill Fennelly, play their home games at the Hilton Coliseum in Ames, Iowa as members of the Big 12 Conference.

The Cyclones finished the 2023–24 season 21–12, 12–6 in Big 12 play, to finish in a tie for fourth place.

4 seed in the Big 12 women's tournament, they defeated Baylor in the quarterfinals[1] and Oklahoma in the semifinals[2] before losing to Texas in the championship game.

[3] They received an at-large bid to the NCAA tournament as a 7th seed in the Portland Region 4 where they defeated Maryland in the first round[4] before losing an overtime thriller to Stanford in the second round.