The 2022–23 Iowa State Cyclones women's basketball team represented Iowa State University during the 2022–23 NCAA Division I women's basketball season.

The Cyclones are coached by Bill Fennelly, who is in his 28th season at Iowa State.

They played their home games at Hilton Coliseum in Ames, Iowa as members of the Big 12 Conference.

The Cyclones defeated West Virginia in the quarterfinals of the Big 12 Tournament before falling to Texas in the semifinals.

2022–23 Iowa State Cyclones men's basketball team