The 2024–25 LEN Euro Cup is the 33rd edition of Europe's secondary club water polo competition organised by European Aquatics.

As there are two vacant spots in pot 2, those places were occupied by the two highest ranked clubs from the European Aquatics club rankings who didn't take part in the Champions League Qualification round (Recco Waterpolo and Szolnoki Dozsa-Praktiker).

[5] Regarding, pots 3, 4 and 5 consist of the clubs who didn't take part in the Champions League qualification round.

The seeding of these clubs are based on the following: Jug AO Dubrovnik BVSC-Manna ABC (H) Spandau 04 VK Šabac (H) CN Barcelona (H) HAVK Mladost Zagreb (H) AN Brescia CC Ortigia Dinamo București NC Vouliagmeni

Pays d'Aix Natation (H) VK Banja Luka Enka Istanbul Recco Waterpolo Szolnoki Dozsa-Praktiker (H) Panionios GSS (H) Primorje EB Rijeka Endo Plus Service Honvéd GS Apollon Smyrnis Team Strasbourg Solaris Šibenik Triglav Kranj (H) SV Ludwigsburg 08 CN Terrassa Tenerife Echeyde ASC Duisburg CN Sant Andreu Panathinaikos VK Valis Vega OSC Potsdam Iren Genova Quinto OSC Budapest De Akker Team VA Cattaro Kotor Budva Budvanska Rivijera (H) 26–29 September 2024, Šabac, Serbia

In the eighth-finals draw, the teams were split into two draws, one containing the four teams who finished fourth in the Champions League group stage, who would be pitted up against a Euro Cup group winner.