The 2024–25 Women's EHF Champions League is the 32nd edition of Europe's premier club handball tournament, running from 7 September 2024 to June 2025.

Matches are played in a double round-robin system with home-and-away fixtures, fourteen in total for each team.

The knockout stage includes four rounds: the playoffs, quarter-finals, and a final-four tournament comprising two semifinals and the final.

The eight quarterfinalist teams are paired against each other in two-legged home-and-away matches, with the four aggregate winners qualifying to the final-four tournament.

[4] The fixed place for Russia was vacant since the country and its clubs were not admitted to participate in the EHF competitions due to the Russian invasion of Ukraine.