The 2024 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Big South–OVC Football Association during the 2024 NCAA Division I FCS football season.

The Panthers were led by third-year head coach Chris Wilkerson and played their home games at O'Brien Field located in Charleston, Illinois.

The Big South-OVC Conference released their preseason poll on July 17, 2024.

The Panthers were picked to finish second in the conference.

[1] [2][3] at Memorial Stadium • Champaign, IL at O'Brien Field, Charleston, IL at Martin Stadium • Evanston, IL at Hancock Stadium • Normal, IL at O'Brien Field • Charleston, IL at O'Brien Field, Charleston, IL at Nissan Stadium • Nashville, TN at Graham Stadium • Martin, TN at O'Brien Field • Charleston, IL at Ernest W. Spangler Stadium • Boiling Springs, NC at O'Brien Field • Charleston, IL No scoring plays No scoring plays at Tucker Stadium • Cookeville, TN