[22] In China, shaking was felt in Shanghai, Suzhou, Shenzhen, Guangzhou, Shantou, and parts of Fujian,[23][24] Zhejiang, and Jiangsu provinces.

[30][31] The Ministry of Natural Resources of the People's Republic of China issued a second-highest level orange tsunami alert, warning of potential localized waves that could cause significant damage in affected coastal areas.

The CWA Seismology Center later clarified that it had sent out two alerts that covered the immediate area of the epicenter as well as parts of southern and central Taiwan but not the Taipei area, adding that conditions for issuing a national-level warning depended on the earthquake measuring a magnitude above five and its intensity reaching four on the CWA's seven-level scale.

[73] In Hualien City, two houses, the nine-story Uranus building and a restaurant collapsed, trapping many people inside.

[40] The Legislative Yuan building also sustained damage to its walls and ceilings,[35] while debris fell from the Liberty Square archway of Chiang Kai-shek Memorial Hall.

[86] Power outages affected 371,869 homes in Taiwan according to the Ministry of Economic Affairs,[63] of which, 14,833 were in Taichung; 5,306 were restored within approximately 25 minutes of the earthquake.

[24] High-speed railway services across Taiwan were partially suspended and major expressways in the eastern part of the island were closed.

[96][97] At the distillery of the Taiwan Tobacco and Liquor Corporation in Hualien, around 192,000 alcohol bottles were shattered, causing financial losses of at least NT$14 million (US$435,845).

Crop losses reached up to NT$10,000 and affected 0.3 hectares of farmland, primarily those cultivated with wood ear mushrooms.

[112] Incumbent Taiwanese president Tsai Ing-wen expressed concern about the damage and ordered the ROC Armed Forces to support the local government in Hualien and others parts of the island in rescue missions.

Vice-president and president-elect Lai Ching-te called on the public to be careful and stay calm and announced the formation of an emergency centre to deal with the disaster.

[61][114] Chen also announced that the Directorate General of Budget, Accounting and Statistics would allocate NT$300 million (US$9,366,144) in disaster relief to the Hualien County government and would exempt from taxation income received by affected residents taking up temporary employment because of the earthquake.

Tsai, Lai, Chen and Vice Premier Cheng Wen-tsan also pledged to donate a month's worth of their salaries for disaster relief.

[115] Tsai also warned citizens against non-essential travel to mountains for the long weekend brought about by the Qingming Festival, which began a day after the earthquake.

[116] On 10 April, Tsai visited affected areas of Hualien County and Taroko National Park, where she met with rescue workers.

[55] The mayor of Kaohsiung, Chen Chi-mai, also ordered the deployment of a rescue team and dogs to Taroko National Park.

[126] The New Taipei City Government opened 15 shelters for 269 displaced residents[63] and offered free bus rides to alleviate complications on transportation brought by the earthquake, particularly on the railway system.

[82] Several semiconductor firms, including Powerchip, InnoLux, UMC, King Yuan Electronics Company [zh], Taimide Tech, and TSMC temporarily suspended operations and evacuated their facilities in Hsinchu.

[35] The Health Ministry and the Hualien County government set up dedicated bank accounts and online platforms for receiving earthquake-related donations.

[115] The Red Cross Society of the Republic of China and the Tzu Chi foundation provided meals and shelters to displaced residents.

[137] Taiwan's tourism administration began offering subsidies for tourists travelling to the area after the earthquake, which were extended after they were initially rolled out.

[138] The Taiwan Affairs Office of the People's Republic of China (PRC) said it was highly concerned with the earthquake and was willing to provide disaster relief assistance.

[66] Lai Ching-te, however, wrote to Japanese prime minister Fumio Kishida on X, "Let us continue to help each other and join hands to overcome these difficult times".

This is the second instance of Taipei rebuffing China's aid; after the 2018 Hualien earthquake, it turned down a $3 million donation from the PRC as well as its offer of search and rescue workers, but later accepted assistance from other countries.

[140] On 4 April, the Taiwanese foreign ministry condemned the PRC for its "shameless use of the Taiwan earthquake to conduct cognitive operations internationally" after Geng Shuang, China's deputy ambassador to the United Nations, said China is "ready to provide disaster relief" and thanked "the international community for their care and good wishes" at a UN meeting.

[155] On 7 April, the Manila Economic and Cultural Office (MECO), the de facto embassy of the Philippines in Taiwan, distributed humanitarian aid to Overseas Filipino Workers in Hualien.

[156] Multinational firms such as Japan's Kura Sushi and South Korea's Coupang pledged NTS$2 million each for disaster relief, while FamilyMart and 7-Eleven opened donation channels in their respective mobile applications.

[115] Other Japanese companies such as LY Corporation, Rakuten, and Toyota raised a combined total of more than 258 million yen in donations.

[132] The Red Cross Society of the Republic of China received a 10 million yen (US$65,903) donation from Japanese musician Yoshiki.

[115] The Yomiuri Giants, who play in the Nippon Professional Baseball pledged 10 million yen (US$66,112) and set up a three-day fundraiser starting on 5 April, citing their exhibition games in Taiwan in March 2024 as a reason.