The 2024 Knoxville Challenger was a professional tennis tournament played on indoor hard courts.

It was the 20th edition of the tournament which was part of the 2024 ATP Challenger Tour.

It took place in Knoxville, United States between 4 and 10 November 2024.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as a special exempt: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: