It featured all-star squads from Major League Soccer (MLS) and Liga MX of Mexico—the third edition to use the inter-league format.

The All-Star Game was played two days before the start of the 2024 Leagues Cup, an international competition featuring all clubs from MLS and Liga MX.

[4] Real Salt Lake forward Cristian Arango, who was voted onto the roster, was suspended by the league on July 15 for a violation of the MLS anti-harassment policy.

Real Salt Lake midfielder Diego Luna and Colorado Rapids defender Moïse Bombito were announced as replacement coach selections on July 19.

[8][9] Luciano Acosta of FC Cincinnati, the reigning league MVP, was named captain of the MLS All-Star Team for the second consecutive year.

[10] André Jardine was selected as the manager of the Liga MX All-Stars after winning the Balón de Oro award for Best Head Coach of the Season.

[12] The first half of the Liga MX All-Stars roster was announced on June 30, 2024, as part of the Balón de Oro awards.