The ruling coalition formed an electoral alliance called Sigamos Haciendo Historia, consisting of Morena, PVEM, and PT, with the goal of securing a supermajority to pass outgoing President Andrés Manuel López Obrador's "Plan C," a package of eighteen constitutional amendments.

In what many described as a wave election,[3] Sigamos Haciendo Historia won 30 of 32 races, securing most of the first-past-the-post seats and making gains in states governed by the opposition, such as Chihuahua, Coahuila, Durango, Guanajuato, Jalisco, Nuevo León, and Yucatán.

[14] The coalition will field common candidates for the Senate in all states except Baja California, Chiapas, Guerrero, Hidalgo, Oaxaca, Querétaro, San Luis Potosí, Sinaloa, Sonora, Tabasco, Tamaulipas and Tlaxcala.

[18][19] In 2018, Martha Márquez Alvarado and Juan Antonio Martín del Campo, representing the Por México al Frente electoral alliance, were elected with 35.72% of the vote.

Incumbent Senator Juan Antonio Martín del Campo and local deputy María de Jesús Díaz Marmolejo were nominated by the Fuerza y Corazón por México coalition.