They were led by head coach Darin Hendrickson, in his 17th season with the program.

The 2023 Saint Louis team finished the season with a 33–23 (15–9) record.

They reached the finals of the 2023 Atlantic 10 Conference baseball tournament where they lost to George Mason.

Ethan Bell, Hayden Moore, and Cole Smith were named to the All-Atlantic 10 Preseason team.

Saint Louis was picked to win the conference and received three first-place votes.