St. Louis City SC opened the 2024 season in the 2024 CONCACAF Champions Cup playing against the Houston Dynamo.

St. Louis earned its berth in the continental cup by winning the Western Conference of MLS.

[2] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

St. Louis City SC was not sent to the tournament, and neither was their MLS Next Pro team St. Louis City 2 following the deal reached on March 1, 2024 due to their participation in the 2024 CONCACAF Champions Cup.

The MLS Goal of the Matchday is selected each Matchday of the regular season through fan voting in a process conducted by MLS Communications.