Democratic U.S. Representative Ruben Gallego defeated Republican former news journalist Kari Lake to succeed Democrat-turned-independent incumbent Kyrsten Sinema, who did not seek a second term.

[1] Sinema, who was elected as a Democrat, was considered vulnerable to a primary challenge due to frequently opposing her party's legislative agenda.

[2][1] Lake, the Republican nominee in the 2022 Arizona gubernatorial election, won her party's nomination with 55% of the vote against Pinal County sheriff Mark Lamb.

[4][5] Gallego defeated Lake by 2.4 percentage points, a closer race than polls had projected for most of the campaign.

This was the first time that Arizona voted for candidates of different political parties for U.S. senator and president since Democrat Dennis DeConcini was reelected as Republican George H. W. Bush carried the state in 1988.

[12] Sinema did not support the Inflation Reduction Act until after Democratic leaders agreed to remove a provision closing the so-called carried interest tax loophole, the closure of which would have raised taxes on hedge fund owners and investment managers.