Incumbent Republican Senator Rick Scott won re-election to a second term, defeating Democratic nominee Debbie Mucarsel-Powell.

[1] Scott, then the governor of Florida, was first elected to the U.S. Senate in 2018 by 0.1 points, defeating then-incumbent Bill Nelson.

[2] With the benefit of incumbency and the state's rightward trend, most political pundits considered the race to be favoring Scott to win re-election.

On Election Day, Scott won by 12.8 percentage points, a significantly larger margin than most pre-election polls had suggested.

Scott won majority-Hispanic Miami-Dade County for the first time in all of his statewide races.