This was the first time Michigan voted for candidates of different political parties for U.S. senator and president since Democrat Don Riegle was reelected as Republican George H.W.

[8] This race was considered to be competitive given the state's nearly even partisan lean and that there was no incumbent; however, most polls and ratings had Slotkin as the slight favorite to win.

[9][10] In-fighting among Michigan Republicans after the 2022 elections left the state party poor in funding for the U.S. Senate race[11] and defaulting on a bank loan.

[18] She continued to dominate fundraising in the second quarter of 2024 outpacing her Republican opponent by as much as three-to-one with 95% of her contributions coming from donors giving $100 or less according to the campaign.

[19][20] Slotkin released the first TV ad of the primary campaign on May 28 which focused on her work in national security in the George W. Bush and Obama administrations.

[21] In November 2023, Hill Harper claimed that he had been offered $20 million in campaign contributions from former Motown Motion Picture Studios owner Linden Nelson if he would drop out of the Senate race to mount a primary challenge against U.S. Representative Rashida Tlaib.

[22][25] Nasser Beydoun subsequently also alleged that former Michigan Democratic Party chair Lon Johnson had approached him with an identical offer to drop out of the Senate race and primary Tlaib.