Incumbent one-term Republican Senator Marsha Blackburn defeated state representative Gloria Johnson with 63.8% of the vote.

Although Gloria Johnson campaigned for the Senate seat, she simultaneously sought and won re-election to the State House in the 90th district, where she ran unopposed in that race.

[20] Initially, 2020 Democratic nominee for senate, Marquita Bradshaw was seen as the early favorite but months after her announcement, State Representative Gloria Johnson entered the race.

[12][13] Throughout the campaign, Blackburn consistently led Johnson in the polls and enjoyed a significant financial edge, with a $9 million fundraising advantage.

On October 16, the two candidates were scheduled to debate, but Blackburn declined to attend, leaving Johnson to face an empty chair.