The 2025 Iowa State Cyclones football team will represent Iowa State University as a member of the Big 12 Conference during the 2025 NCAA Division I FBS football season.

They are led by Matt Campbell in his tenth year as their head coach.

The Cyclones will play home games at Jack Trice Stadium located in Ames, Iowa.

[1][2] at Aviva Stadium • Dublin, Ireland at Jack Trice Stadium • Ames, Iowa at Jack Trice Stadium • Ames, Iowa at Centennial Bank Stadium • Jonesboro, Arkansas