The 2025 Omloop Het Nieuwsblad was the 20th edition of the Omloop Het Nieuwsblad road cycling one day race, which was held on 1 March 2025 as part of the 2025 UCI Women's World Tour calendar.

The race was won by Belgian rider Lotte Claes [fr] of Arkéa–B&B Hotels Women, after an early breakaway stayed away from the main field.

[1] Fifteen UCI Women's WorldTeams, six UCI Women's ProTeams, and three UCI Women's Continental Teams made up the twenty-four teams that participated in the race.

[2] UCI Women's WorldTeams UCI Women's ProTeams UCI Women's Continental Teams