It operates S-300 missile systems and is subordinated to the Air Command South.

In 1992, following the Dissolution of the Soviet union, the 208th Guards Anti-Aircraft Missile Brigade of the 60th Air Defense Corps of the Soviet Army came under the jurisdiction of Ukraine and became part of the Ukrainian Armed Forces.

On 19 November 2017, near the village of Kamianka, a separatist projectile hit a dugout leading it to catch fire, one soldier of the brigade was saved but two soldiers of the brigade (Oleksandr Serhiyovych Kuzmenko[3] and Vitaly Petrovych Pasichnyk[4]) along with a paratrooper were killed as a result of Carbon monoxide poisoning.

From the first minutes of the Russian invasion of Ukraine, the brigade took part in the defense of Ukraine claiming the neutralization of 5 Russian fixed wing aircraft, 8 helicopters, 28 cruise missiles, and 31 UAVs of various types in 2022.

[5] On 19 October 2022, the brigade shot down a Ka-52 helicopter at around 10:30 a.m.[6] The commander of the brigade Anatoly Valeriyovych Paleny was also killed in action on 28 October 2022 whilst serving in Mykolaiv.