The 21st Mixed Aviation Division (Serbo-Croatian: 21. mešovita vazduhoplovna divizija/ 21. мешовита ваздухопловна дивизија) was a Yugoslav Air Force unit established in 1949.

The 21st Mixed Aviation Division was formed in 1949 due to the plan of the expansion of Yugoslav Air Force formation.

It was an independent unit under direct command of Air Force HQ.

It was disbanded by the order from June 27, 1959, year per the "Drvar" reorganization plan.

The commanders of division were August Canjko, Blažo Kovačević, Milenko Lipovščak and Radoje Ljubičić.