The 21st Virginia Cavalry Regiment was a cavalry regiment raised in Virginia for service in the Confederate States Army during the American Civil War.

It fought in Southwest Virginia, East Tennessee, and the Shenandoah Valley.

It took an active part in various conflicts in East Tennessee, western Virginia, and in the Shenandoah Valley.

Peters, Lieutenant Colonel David Edmundson, and Major Stephen P. Halsey.

This article about a specific military unit of the American Civil War is a stub.