[1] The ceremony was hosted by television personalities Jey Mammón and Eleonora Pérez Caressi.
[2] Nathy Peluso received the most nominations, with nine, followed by Fito Páez and Bizarrap with six each.
The list of performers was unveiled on July 16, 2021, and consisted of forty-two artists including headliners Fito Páez, Cazzu, Ciro y los Persas, Soledad, Luciano Pereyra, María Becerra, David Lebón, Miranda!
[3] Nathy Peluso and Fito Páez won the most awards of the night, with four each.
Peluso's wins included Record of the Year for her album Calambre and Best New Artist, while Páez's included Album of the Year (Gardel de Oro Award) and Best Rock Album for La Conquista del Espacio.