[4] After graduating from King Juan Carlos University, Peluso relocated to Barcelona to pursue a professional career in music, with her first releases Esmeralda (2017) and La Sandunguera (2018) being confected independently.

[8][9] She has also collaborated with Christina Aguilera, Karol G, and C. Tangana, with the latter one's duet "Ateo" debuting atop the Spanish charts.

After leaving the degree program, she moved to Madrid to study fine arts at the King Juan Carlos University.

[22] Additionally, she also wrote instant poetry as an income, which caused her an interest in hip-hop music after meeting producers of the genre.

[6] In October 2017, Peluso self-released a seven-track mixtape titled Esmeralda, which included her debut single "Corashe".

She later embarked on a tour with her band Big Menu that had over a hundred concerts, including gigs at BBK Live, Sónar and the Festival Internacional de Benicàssim.

[26] Peluso published the book Deja Que te Combata in May 2019, a compilation of her thoughts, reflections, stories, and past and upcoming projects.

[28] She also partnered with Samsung to be part of their Somos Smart Girl campaign alongside Blanca Suárez, Sandra Barneda and Carolina Marín.

[31] In 2020, Peluso reached the attention of the general public and the mainstream audience after Operación Triunfo contestant Anaju sang "La Sandunguera" on prime time to keep participating in the show.

[32] After that, Peluso was invited to the show on Women's Day to promote her new single "Business Woman", defined as a feminist anthem.

[33] During the peak of the COVID-19 pandemic, Peluso released a musical collaboration with urbano artist Rels B titled "No Se Perdona", which had great commercial success.

[49] On 3 July 2021, Nathy Peluso announced her first solo single since the release of her debut album, titled "Mafiosa", which peaked at 89 in Spain.

[50] In September, she took part in the Spotify Singles song series in which she covered "La Despedida" by Daddy Yankee to critical acclaim.

[51] The following month, she collaborated with C. Tangana on his song "Ateo" (which became Peluso's first number one single in Spain) and was featured on Christina Aguilera's "Pa Mis Muchachas" alongside Becky G and Nicki Nicole.

[52][53] In December, Peluso reinterprated Camilo Sesto's "Vivir Así es Morir de Amor" to great commercial success.