The regiment was originally formed as the 253 (North Irish) Field Ambulance, upon the formation of the TAVR in 1967.

In 2006, under the Delivering Security in a Changing World reforms, the field ambulance was re-designated as a medical regiment, becoming 253 (North Irish) Divisional General Support Medical Regiment.

[2] Under Army 2020, the regiment dropped the divisional title, to become 253 (North Irish) Medical Regiment, transferred to 2nd Medical Brigade, and was tasked to support 1st (United Kingdom) Division.

[3] Under the Future Soldier programme, the hospital amalgamated with 204th (North Irish) Field Hospital to form the new 210th (North Irish) Multi-Role Medical Regiment in September 2023.

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