Designation changed to 25th Missouri Infantry Regiment in September, 1861.
1st Brigade, 2nd Division, District of Southeast Missouri, Dept.
New Madrid, Mo., District of Columbus, Ky., 6th Division, 16th Army Corps, Dept.
Moved to Iron Mountain, thence to St. Joseph, Mo., and operating against guerrillas in Northwest Missouri until June.
Ordered to New Madrid, Mo., and garrison duty there and reconstructing fortifications until February, 1864.