After the July 11, 1861, Battle of Rich Mountain, the regiment was severely depleted due to Col. Pegram's surrender of Camp Garnett, as discussed below.

Included in the dead were Upshur Gray privates Henry Clay Jackson and Oscar Sherwood, whose names can be seen engraved in the rock that they defended to this day.

After Jackson's campaign finished, the regiment was assigned to General Early's, J.R. Jones', and W. Terry's Brigade, Army of Northern Virginia.

While depleted, the 25th Virginia took an active part in the campaigns of the army from the Seven Days' Battles to Cold Harbor, then fought with Early in the Shenandoah Valley and in various conflicts around Appomattox.

[1] The field officers were: Brigadier General John C. Higginbotham (Posthumous), Colonels George A. Porterfield, and George H. Smith; Lieutenant Colonels Patrick B. Duffy, Jonathan McGee Heck, Robert D. Lilley, and John A. Robinson; and Majors Wilson Harper, Albert G. Reger, and William T. Thompson.