Deployed to the China-Burma-India Theater in March 1942, initially arriving at Karachi, India moving via Australia and Ceylon.

The squadron flew strafing, bombing, reconnaissance, and patrol missions in support of Allied ground troops during a Japanese offensive in northern Burma in 1943.

Was reequipped with North American P-51D Mustangs in 1945 to defend the eastern end of the route over the Hump, and to guard air bases in the Kunming area.

Conducted undergraduate pilot training at Vance Air Force Base, Oklahoma, 1990–1992, flying Northrop T-38 Talons until inactivated as part of the post Cold War shutdown.

Reactivated in 2008 at Nellis AFB, Nevada as part of the USAF Weapons School, specializing in training and producing MQ-1 Predator and MQ-9 Reaper pilots and sensor operators.