Established as a World War II Tenth Air Force North American B-25 Mitchell bomb group in India, the unit served as part of Strategic Air Command during the early part of the Cold War as a Boeing B-47 Stratojet wing, before becoming an intercontinental ballistic missile unit in 1962.

Today, the 341st is one of three remaining United States Air Force wings that maintain and operate the LGM-30 Minuteman III intercontinental ballistic missile.

The mission of the 341st Missile Wing is to defend America with safe, secure, effective nuclear forces and combat-ready airmen.

The 341st Missile Wing has its origins in the China-Burma-India Theater of World War II, being activated in India on 15 September 1942.

Planes and crews of the 22d Bombardment Squadron had been flying recon and tactical missions over north and central Burma, also since July.

It bombed bridges, locomotives, railroad yards, and other targets to delay movement of supplies to the Japanese troops fighting in northern Burma.

However, the 490th "Burma Bridge Busters" remained in India, under the command of Major-General Howard Davidson's Tenth Air Force.

They also bombed and strafed such targets as trains, harbors, and railroads in French Indochina and the Canton-Hong Kong area of China.

Received a DUC for developing and using a special (glip) bombing technique against enemy bridges in French Indochina.

In August 1964, the Air Force announced plans to build an additional 50 silos assigned to the 341st to house LGM-30F Minuteman II missiles.

The unit won its first Blanchard Trophy in SAC's annual Olympic Arena missile competition in 1976 and again captured this most coveted prize in 1986, 1990, and 1991.

In March 1995, the Base Realignment and Closure (BRAC) Commission selected the 321st Strategic Missile Wing at Grand Forks AFB, North Dakota for deactivation.

[8] A July 2009 inspection conducted by the Air Force Audit Agency found that 48 percent of the 711 unused nuclear weapons-related materials handled by the wing were incorrectly tracked or recorded.

The wing received an "unsatisfactory" rating due to "tactical level errors" made during one of the many exercises during its inspection.

[12] After an investigation, the wing's commander, Colonel Robert Stanley voluntarily resigned and retired from the Air Force.