However, on February 12, 1870, the militia were reduced to en cadre until their disbandment in April 1898 after Puerto Rico was ceded to the United States.

[b] Almost two decades after, on 1917 and at the brink of World War I, Puerto Ricans were granted American citizenship.

This series of events would establish a long parallel history between the 295th and the 296th Infantry Regiments.

[c][d] A few years later, on January 1, 1944, the regiment was activated and served in the American Theater of war in the Panama Canal Zone until February 20, 1946.

Most recently, Company C, 1st Battalion, 295th Infantry Regiment (C/1-295) spent a year running security escort missions throughout southern Iraq and security patrols around Baghdad International Airport as part of Operation Iraqi Freedom in 2006.