[2] The installation used for training of the Puerto Rico National Guard was formally named "Campamento Santiago" pursuant to an order issued by the General Quarters of the United States Army on July 1, 1975.

[4] From 1990 to 1991, military units in Puerto Rico such as the 92nd Maneuver Enhancement Brigade reported to Camp Santiago for initial training in preparation before deployment to Operation Desert Storm in Kuwait.

Camp Santiago also had a role in training National Guard and Reserve soldiers in Puerto Rico for Operation Enduring Freedom during the War in Afghanistan (2001–2021).

Some old barracks were demolished and replaced with new barracks; Other facilities include the Sustainment Automation Support Management Office (SASMO), a Puerto Rico National Guard Museum, Theater, Dining Facilities, Base Chapel, Fire Station, a pool for recreation and water training exercises, a cyber café (computer classroom/laboratory), Troop Medical Clinic, The Brig Gen. Victor J. Torres Fitness Center, ID Card office, MWR Community Center and AAFES post exchange and gas station on base.

Future projects for the Camp Santiago Joint Maneuver Training Center (CSJMTC) includes a land navigation course, a live shooting house, and a military pistol qualification range.

The Puerto Rico Rifle and Pistol Association hold their state championship every year at Camp Santiago, with participants from the military, law enforcement agencies, and civilian organizations.

Military youth groups such as the Civil Air Patrol and the United States Naval Sea Cadet Corps conduct Summer Encampment at Camp Santiago.