The 2nd Life Grenadier Regiment (Swedish: Andra livgrenadjärregementet), designation I 5, was a Swedish Army infantry regiment that traced its origins back to the 16th century.

The regiment's soldiers were recruited from the province of Östergötland.

The regiment has its origins in fänikor (companies) raised in Östergötland in the 16th century.

Sekundchef was a title used until 31 December 1974 at regiments that were part of the King's Life and Household Troops (Kungl.

Maj:ts Liv- och Hustrupper).