It managed deployed Strategic Air Command tankers and bombers participating in combat operations in Southeast Asia until it was inactivated on 30 September 1975.

The wing remained in the Far East, required to maintain combat readiness, and on 15 August 1953 Kadena became its permanent base.

It replaced the propeller-driven B-29s with new Boeing B-47E Stratojet swept-wing medium bombers in 1955, capable of flying at high subsonic speeds and primarily designed for penetrating the airspace of the Soviet Union.

SAC organized the 4258th at U-Tapao on 2 June 1966 and assigned it to the 3d Air Division[2] to supporting deployed Boeing KC-135 Stratotankers that engaged in combat operations over Southeast Asia during the Vietnam War.

[2] The following year, the wing added the 4258th Munitions Maintenance Squadron, which enabled it to support Boeing B-52 Stratofortress operations as well.

In 1970, in order to perpetuate the lineage of inactive bombardment units with illustrious World War II records, SAC received authority from Headquarters, USAF to discontinue its two Major Command controlled (MAJCON) strategic wings in the Pacific and replace them with Air Force controlled (AFCON) units, which could carry a lineage and history.

[3] On 1 April 1970, the 4258th SW was discontinued and replaced by the 307th Strategic Wing which assumed its mission, personnel, and equipment on 1 February 1963.

Using aircraft and crews deployed from the United States, the 307th conducted conventional bombardment operations and provided KC-135 aerial refueling (Young Tiger Tanker Task Force) of U.S. aircraft in Southeast Asia as directed through the Military Assistance Command, Vietnam.

[1] On 4 June 2012 the 707th Maintenance Squadron reached a milestone with the certification of their first nuclear and conventional load crew on the B-52H Stratofortress.

This event provided a forum for outreach with civilian and military leadership from the Czech Republic, Slovakia, and populations from surrounding nations.

[1] In August and September 2017, the 307th Bomb Wing supported and participated in Exercise AMPLE STRIKE, which was Czech Republic led with two B-52s and two B-1s.

In May and June 2018, the 489 BG led an integrated Bomber Task Force in support of the joint, multinational maritime-focused Exercise BALTOPS in the Baltic Sea.

The exercise enhances flexibility and interoperability, and demonstrate resolve among allied and partner forces in defending the Baltic region.

At the same time the Wing supported the Bomber Task Force in Europe with a B-52 flying missions over Romania, the Arctic Circle and other European locations.