Initially, it assumed responsibility for an area including Maine, Vermont, Massachusetts, New Hampshire, and part of New York.

[6] Twelve McDonnell F-4 Phantom IIs of VF-41 moved to augment air defense forces on Key West, and additional crews were added to the VF(AW)-3 detachment to permit it to maintain aircraft on continuous alert.

[4] The 331st Fighter-Interceptor Squadron deployed 18 Delta Daggers to Homestead Air Force Base bringing the number of Deuces there to 32.

[8] However, the F-102s of the 331st were soon replaced with F-102s from 325th Fighter-Interceptor Squadron in order to have planes armed with Mighty Mouse rockets[9] to improve low altitude intercept capability[10] Patrick Air Force Base, Florida received a dozen Delta Darts from the 49th Fighter-Interceptor Squadron.

[8] To improve fighter-on-fighter capability draft mobilization orders were issued for the 122d, 151st, 157th and 159th Fighter-Interceptor Squadrons, but were never finalized and the Air National Guard did not take part in the crisis.

A battery of MIM-23 Hawk missiles from the 6th Battalion, 61st Artillery was transferred from Fort Meade to defend Key West.

Hawks from the 8th Battalion, 15th Artillery at Fort Lewis were also deployed to MacDill Air Force Base and to Patrick.

[15] Later, beginning in 1966, the area expanded to include Mississippi, Alabama, Georgia, and parts of South Carolina, Louisiana and Florida when it assumed responsibility for the mission of the inactivated Montgomery Air Defense Sector.