333 West Wacker Drive is a highrise office building in Chicago, Illinois, noted for its reflection of the curves of the Chicago River on its river-facing side.

On the side facing the Chicago River, the building features a curved green glass façade, while on the other side the building adheres to the usual rectangular street grid.

The architecture firm Kohn Pedersen Fox Associates who designed 333 also designed the high-rise buildings 225 W Wacker to the east, and 191 N Wacker Drive to the south.

333 Wacker Drive was featured in the 1986 movie Ferris Bueller's Day Off as the building containing Ferris Bueller's father's offices, and was voted "Favorite Building" by the readers of The Chicago Tribune in 1995.

The building is used for exterior shots of Crows Security headquarters in Batwoman.