The company's duties in Panama, Germany and Italy were primarily assisting the active-duty component in conducting law-and-order base security.

In Nicaragua and Belize, the company was tasked with guarding engineers who built roads, schools and drilled wells for drinking water.

[2] Following September 11, 2001, the 333d was activated by Governor George Ryan under Title 32 status for increased security at Illinois commercial airports.

[4] In February 2003, the unit was activated in support of Operation Iraqi Freedom and deployed to Iraq in May of the same year.

[6][7] From 2008 to 2009, the 333d served as a force protection unit, guarding U.S. troop perimeters and escorting convoys in Afghanistan in support of Operation Enduring Freedom.