The regiment was organized in March 1862 at Belton, Texas and surgeon Peter C. Woods was appointed to command it.

It marched to Brownsville, Texas, in spring 1863 and later joined Hamilton P. Bee's brigade.

This brigade transferred to Louisiana where it fought at Mansfield, Pleasant Hill, Blair's Landing, and Yellow Bayou during the Red River campaign in 1864.

Afterward, the regiment traveled to Crockett, Texas, and then Galveston, where it was present when the men were paroled in June 1865.

This article about a specific military unit of the American Civil War is a stub.