The wing was first organized in 1966 as the 377th Combat Support Group at Tan Son Nhut Airport, Republic of Vietnam.

It began phasing down in early 1973 and transferred most of its remaining assets to the Vietnamese Air Force before inactivating.

The group provided support for Seventh Air Force flying operations with from June to December 1966, and again after September 1971.

The wing operated the Southeast Asia Central Instructor Pilots School, in which the 360th Tactical Electronic Warfare Squadron used C/EC-47s, from 15 February until about November 1972.

[2] As the wing phased down for inactivation from February 1973, it transferred many assets to Republic of Vietnam Air Force.

To support this mission, the 377th Air Base Wing has the largest security forces squadron in the command.

In November 2009 the wing, commanded by Colonel Michael S. Duvall, failed its nuclear surety inspection.

[1] In November 2022, the wing added the 377th Test and Evaluation Group, stationed at Vandenberg Space Force Base, California.

[4] This article incorporates public domain material from the Air Force Historical Research Agency