It is situated between the LATTC/Ortho Institute and Slauson stations on the J Line, a bus rapid transit route which runs between El Monte, Downtown Los Angeles and San Pedro as part of the Metro Busway system.

The station consists of two side platforms in the center of Interstate 110 above 37th Street, adjacent to the University of Southern California campus.

[5] 37th Street/USC station is used by the Metro J Line bus rapid transit route which runs between the El Monte Station in El Monte, Downtown Los Angeles and the Harbor Gateway Transit Center in Gardena, California, with select trips continuing onto San Pedro.

[7] J Line buses run 24 hours a day between El Monte Station, Downtown Los Angeles, and the Harbor Gateway Transit Center, as route 910.

[8] In addition to J Line buses, the busway platforms at 37th Street/USC station are also served by the all-day Los Angeles Metro Bus route 460 to Disneyland.