The 38th Sustainment Brigade’s origins date to the Mexican Border Crisis when this unit function as a combat arms company.

The Indiana National Guard unit was organized and federally recognized on June 3, 1916 as Headquarters Company, 3rd Battalion, 2nd Infantry in Indianapolis.

After the Armistice of 11 November 1918 was signed, the division was demobilized March 8, 1919, at Camp Taylor, Louisville, Kentucky.

After World War I, Headquarters Company, 3rd Battalion, 152nd Infantry was reorganized and federally recognized September 22, 1921, at Indianapolis.

When the unit's mission changed from service in the European to Pacific theatres, subsequent to Japan's attack on Pearl Harbor, the 38th Division then underwent three years of training at Camp Shelby, Mississippi.

The 38th Infantry Division was then assigned the M-7 Operation to assist in eradicating the presence of Japanese troops in the Philippine Peninsula and Islands in Manila Bay as part of a five-phase plan, which included clearing Highway 1 in the north, the Fort Stotsenburg area in the very south (initiated by the landing at Mariveles), the Zambales Mountains between, and the Islands of Caraballo, Carabao, and El Fraille (Fort Drum).

Legend has it on this day General Douglas C. MacArthur declared the 38th Infantry Division, "The Avengers of Bataan".

In May 2006, HHC Division Support Command was ordered into active federal service for deployment to the Iraq War (2003-2010), Operation Iraqi Freedom.

This was the first time in Indiana National Guard history that a brigade-echelon unit was deployed with a female commander, COL Marjorie Courtney.

Under the name "Task Force Indy" – HHC DISCOM served as the Garrison Command for Victory Base Complex in Baghdad.