In 1943, the squadron flew to Kairouan, Tunisia, and from there, it conducted operations against Italy and Sicily, returning to the UK in November of the same year.

The use of atomic bombs precluded the need for Tiger Force, and 425 was disbanded on 5 September 1945 at RCAF Station Debert, less than three weeks after the Japanese surrender.

A detachment of four CF-18 fighters from the squadron deployed to Romania, at the Mihail Kogălniceanu Air Base in March 2016 to participate in the Resilient Resolve exercise.

[3] The squadron was deployed to Romania previously, at Câmpia Turzii in 2014, as part of NATO's assurance measures in response to Russia's annexation of Crimea.

[4] In 2022, 425 Squadron was again deployed at Mihail Kogălniceanu to participate in NATO's enhanced Air Policing mission in the Black Sea region.