During General William Howe's first attack on Breed's Hill, Nixon was wounded and was withdrawn from the battle.

[4] The 6th Massachusetts composed part of the main body of General Horatio Gates at the Battles of Saratoga.

Colonel John Nixon - Commanded the regiment from May 19, 1775, until August 9, 1776, when he was promoted to brigadier general.

Colonel Benjamin Tupper - Commanding officer January 1, 1783, until the unit was disbanded on June 12, 1783.

Thomas Barnes- Served as captain from January 1777 to March 1779, when he was promoted to major with the 12th Massachusetts.

Joseph Thompson- Served as captain and major from January 1776 until he was promoted to lieutenant-colonel in the 10th Massachusetts in December 1777.